Formulation and Evaluation of Taste Masked Orally Disintegrating Tablet of Tinidazole

Tinidazole is a broad spectrum antiprotozoal agent having bitter taste. The present study concerns to mask the bitter taste of tinidazole as an orally disintegrating tablet (ODT) using Indion 294 and Indion 204 (ion exchange resin) as a taste masking agent. In first method, 1:1, 1:2 and1:3 ratios of drug and resin were stirred for six hour. Percent drug losses were found to be on higher side in this method. In second method, drug-resin complexes were prepared by wet granulation method with different concentration ratios of drug with Indion 294 as well as with Indion 204(1:0.5, 1:1,1:1.5) using lactose as diluent and polyvinylpyrrolidone k-30 as binder. On the basis of disintegration time, optimum concentration of superdisintegrants i.e. crosscarmollose sodium and crosspovidone were found to be 8% w/w. The tablets were prepared by direct compression method using orange flavour and evaluated for taste, weight variation, hardness, friability, disintegration test, content uniformity, dissolution study & FTIR study. The best formulations were found to be containing (1:1.5) drug: Indion 204 & (1:1.5) drug: Indion 294.